IP Journal of Surgery and Allied Sciences
Official Publication of Khyati Education and Research Foundation
Official Publication of Khyati Education and Research Foundation
Online ISSN: 2582-6387
IP Journal of Surgery and Allied Sciences (JSAS) open access, peer-reviewed quarterly journal publishing since 2019 and is published under the Khyati Education and Research Foundation (KERF), is registered as a non-profit society (under the society registration act, 1860), Government of India with the vision of various accredited vocational courses in healthcare, education, paramedical, yoga, publication, teaching and research activity, with the aim of faster and better dissemination of knowledge, we will be publishing the article ‘Ahead more...Case Report
Author Details :
Volume : 6, Issue : 4, Year : 2024
Article Page : 138-140
https://doi.org/10.18231/j.jsas.2024.032
Abstract
Chronic ulcers and non-healing wounds present a significant public health and economic burden, particularly in aging populations. This study aimed to evaluate the efficacy of topical phenytoin in enhancing wound healing, focusing on its effects on fibroblast proliferation, neovascularization, and overall wound repair. A case study was conducted in the Department of Plastic Surgery at a tertiary care center in South India involving a 69-year-old male patient with a non-healing diabetic foot ulcer complicated by Charcot's joint. Regenerative therapy utilized a 5 mg/ml diluted phenytoin solution for wound irrigation, followed by the application of a two-layered collagen scaffold, sterile dressing, and immobilization. Topical application of phenytoin demonstrated a marked improvement in wound healing. Observed outcomes included enhanced granulation tissue formation, reduced inflammation, and improved epithelialization. This study highlights the potential of phenytoin as an accessible, cost-effective, and safe therapeutic agent for chronic wound management. By promoting fibroblast proliferation, inhibiting collagenase activity, and enhancing neovascularization, phenytoin significantly improves wound healing. These findings support the integration of phenytoin in clinical practice for non-healing ulcers, with a recommendation for larger-scale studies to validate its broader applicability.
Keywords: Phenytoin, Wound management, Diabetic ulcers
How to cite : Swetha M, Chittoria R K, Kumar R V, Role of phenytoin solution in the management of diabetic foot. IP J Surg Allied Sci 2024;6(4):138-140
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